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Found 2 clinical trials
Study to Evaluate the Pharmacokinetics (PK) of E7090 and Its Metabolite in Participants With Mild and Moderate Hepatic Impairment Compared to Healthy Participants
The primary purpose of the study is to evaluate the effects of mild and moderate hepatic impairment on PK of E7090 after a single dose administration.
e7090
body mass index
electrocardiogram
moderate hepatic insufficiency
moderate hepatic impairment
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- 19 Feb, 2024
The Effect of Hepatic Impairment on Aprocitentan Pharmacokinetics
This is a prospective, single-center, open-label, single-dose, Phase 1 study, to assess the effect of moderate hepatic impairment due to liver cirrhosis on the pharmacokinetics of aprocitentan (ACT-132577).
kidney function tests
hysterectomy
moderate hepatic insufficiency
oophorectomy
cirrhosis
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- 19 Feb, 2024