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Found 5 clinical trials
Venetoclax SL-401 and Chemotherapy for the Treatment of Blastic Plasmacytoid Dendritic Cell Neoplasm

This phase II trial studies how well venetoclax, SL-401, and chemotherapy works in treating patients with blastic plasmacytoid dendritic cell neoplasm. Venetoclax may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. SL-401 is a recombinant protein consisting of IL-3 linked to a …

oral contraceptives
blastic plasmacytoid dendritic cell neoplasm
treatment regimen
ara-c
hydroxyurea
  • 0 views
  • 19 Feb, 2024
  • 1 location
A Study of IBI377 in Combination With Corticosteroids for the Treatment of First-Line Acute Graft-Versus-Host Disease

The purpose of this study is to evaluate itacitinib in combination with corticosteroids as first-line treatment of participants with Grade II to IV acute graft-versus-host disease (aGVHD).

growth factor
graft versus host disease
corticosteroids
itacitinib
cancer
  • 0 views
  • 19 Feb, 2024
  • 1 location
Safety Pharmacokinetics and Preliminary Efficacy of Isatuximab in Patients Awaiting Kidney Transplantation

Primary Objectives: Phase 1: To characterize the safety and tolerability of isatuximab in kidney transplant candidates. Phase 2: To evaluate the efficacy of isatuximab in desensitization of patients awaiting kidney transplantation. Secondary Objectives: Phase 2: To characterize the safety profile of isatuximab in kidney transplant candidates. To characterize the pharmacokinetic …

isatuximab
nephropathy
kidney transplant
diphenhydramine
sar650984
  • 0 views
  • 19 Feb, 2024
  • 2 locations
Low Dose Ruxolitinib in Combination With Methylprednisolone

This study is to determine the efficacy and safety of combined Low dose Ruxolitinib With Methylprednisone as Initial Therapy for the aGVHD(acute graft-versus-host disease )

cell transplantation
methylprednisolone
allogeneic hematopoietic stem cell transplant
ruxolitinib 5 mg
graft versus host disease
  • 0 views
  • 19 Feb, 2024
  • 1 location
Everolimus Plus Mycophenolic Acid for Kidney Preservation in Liver Transplant Recipients With Impaired Kidney Function

Tacrolimus is the standard immunosuppressive drug used to prevent organ rejection post liver transplant. One side effect of Tacrolimus is nephrotoxicity. Everolimus does not have the nephrotoxicity side effects of Tacrolimus. Replacement of Tacrolimus by Everolimus may have a reduced incidence of renal dysfunction in liver transplant patients who already …

nephropathy
renal toxicity
chronic disease
glomerular filtration rate
hepatitis c
  • 0 views
  • 19 Feb, 2024
  • 1 location