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Calorie Restriction With or Without Metformin in Triple Negative Breast Cancer
Glucose starvation and metformin have synergistic antitumor effects that are mediated through the concomitant inhibition of glycolysis and mitochondrial oxidative phosphorylation. The BREAKFAST trial will evaluate the antitumor activity of combining cyclic fasting-mimicking diet (FMD), which reproduces the in vitro effects of glucose starvation, plus/minus metformin with standard preperative anthracycline-taxane …
gene amplification
anthracycline
curative surgery
potassium
acidosis
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- 19 Feb, 2024