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Found 690 clinical trials
Tissue Retractors for Radiation Therapy of Head and Neck Tumors

The rate of therapy-associated side effects during and after radiotherapy of head and neck tumors is essential. The most effective approach to reducing acute toxicity is to cut out healthy tissue from the radiation field. The distance between the tumor and normal tissue can be individually increased using personalized, 3D …

neck tumor
tumour resection
head and neck cancer
dental caries
head and neck neoplasms
  • 0 views
  • 19 Feb, 2024
HER2-PREDICT: Translational Study of Tumor Samples From DS8201-A-U301 and DS8201-A-U302 Trials.

In order to identify mRNA ERBB2 levels, we will evaluate by gene expression tumor samples from these patients.

fine needle aspiration
erbb2
breast cancer
core needle biopsy
her-2
  • 0 views
  • 19 Feb, 2024
Neoadjuvant Chemotherapy With or Without Metformin in Early Breast Cancer.

Several studies have pointed out a potentially beneficial effect of metformin therapy in diabetic cancer patients. Several studies are investigating the anti-tumor effect of metformin in early breast cancer. However, the enhancing effect of metformin on anti-tumor immunity has only been demonstrated in animal models.

cancer
breast cancer
metastasis
carcinoma
metformin
  • 0 views
  • 19 Feb, 2024
Dose-escalation Study of APG-1387 and Toripalimab in Solid Tumors

An ascending dose study in patients with solid tumors to evaluate the safety, tolerability, pharmacodynamics and efficacy of APG-1387 in combination with toripalimab. A phase II study of 3 cohorts will be included.

neuropathy
lung cancer
alopecia
brain metastasis
non-small cell lung cancer
  • 0 views
  • 19 Feb, 2024
Study of AMG 650 in Adult Participants With Advanced Solid Tumors

To evaluate the safety and tolerability of AMG 650 in adult participants and to determine the maximum tolerated dose (MTD) and/or recommended phase 2 dose (RP2D).

  • 0 views
  • 19 Feb, 2024
A Study of SBT6050 in Patients With Advanced HER2 Expressing Solid Tumors

A first-in-human (FIH) study using SBT6050 in HER2 expressing advanced malignancies

cancer
solid tumor
measurable disease
pembrolizumab
solid tumour
  • 0 views
  • 19 Feb, 2024
Impact of a Resource-based Life Review Intervention on Advanced Cancer Patients

The main objective of the present study is to evaluate the effects of the Revie intervention on the self-esteem of patients diagnosed with an advanced cancer. A pragmatic, two-arm parallel-group, waitlist randomized controlled trial is conducted. The study takes place in the oncology department of the University Hospitals of Geneva …

advanced cancer
cancer
  • 0 views
  • 19 Feb, 2024
Phase Study of the HS-10241 in Patients With Advanced Solid Tumors

In preclinical studies, it demonstrated strong activity against c-Met kinase in vitro and in vivo, and inhibited tumor cell growth. This study is conducted to assess the maximum tolerated dose (MTD) and dose limiting toxicity (DLT), to evaluate the pharmacokinetics, safety and preliminary anti-tumor activity of HS-10241 at single dose …

hysterectomy
oophorectomy
serum pregnancy test
bilateral salpingectomy
solid tumor
  • 0 views
  • 19 Feb, 2024
A Study of ADRX-0405 in Subjects with Select Advanced Solid Tumors

The primary purpose of this study is to assess the safety, tolerability, and pharmacokinetics, and to identify the optimal dose of ADRX-0405 in patients with select advanced solid tumors.

  • 0 views
  • 13 May, 2025
Nivolumab Maintenance in Newly Diagnosed PCNSL With Persistent CSF Circulating Tumor DNA After Completion of First-Line Chemotherapy

Participants will be people with PCNSL who continue to have cell free tumor DNA (cfDNA) in their CSF despite completion of their first treatment (first-line treatment).

primary cns lymphoma
direct bilirubin
ffpe
platelet transfusion
blood transfusion
  • 0 views
  • 19 Feb, 2024