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Found 819 clinical trials
Microbiota and Bone Fragility:Study of the Relation Between Gut Microbiota and Bone Microarchitecture

Gut microbiota regulate metabolism of their human host. Some diseases are associated with variations in gut microbiota diversity and higher fracture risk. Intestinal bacteria synthesize or influence synthesis of factors modulating bone metabolism. The link between gut microbiota and bone was assessed mainly in experimental animal studies. Clinical data, e.g. …

spinal fractures
osteoporosis
bone densitometry
postmenopausal osteoporosis
spinal fracture
  • 0 views
  • 19 Feb, 2024
Understanding Factors That Influence Electronic Cigarette Nicotine Delivery Through PET Imaging of Beta-2 Nicotinic Acetylcholine Receptors

The goal of this proposal is to test the overall hypothesis that e-cigarettes (ECs) provide efficient nicotine delivery to the brain and arterial blood in non-EC-nave smokers and e-cigarette users and that EC liquid characteristics modulate this effect. This study will test the hypothesis through complementary methods that include [ …

  • 0 views
  • 19 Feb, 2024
PATH 2 Purpose: Primary Care and Community-Based Prevention of Mental Disorders in Adolescents

The study is a two-arm comparative effectiveness research trial to that will evaluate the ability of the interventions, Competent Adulthood Transition with Cognitive-behavioral & Interpersonal Training (CATCH-IT) and Teens Achieving Mastery over Stress (TEAMS), to intervene early to prevent depressive illness and potentially other common mental health disorders. Using cluster …

depressive disorder
depressive symptoms
psychiatric disorder
  • 0 views
  • 19 Feb, 2024
Cognitive Outcomes After Dexmedetomidine Sedation in Cardiac Surgery Patients

Anesthesia is a drug induced, reversible, comatose state that facilitates surgery and it is widely assumed that cognition returns to baseline after anesthetics have been eliminated. However, many patients have persistent memory impairment for weeks to months after surgery. Cardiac surgery appears to carry the highest risk of postoperative cognitive …

postoperative cognitive dysfunction
coronary artery bypass graft
thoracotomy
cognitive deficit
cognitive impairment
  • 0 views
  • 19 Feb, 2024
Covid-19 Lockdown and Deviant Sexual Fantasies

The investigators know in fact that certain moments, like anxiety, depression, boredom, psychological unrest are propicious for acting, for violent sexual offenders. The investigators therefore pay extra attention to our patients in such periods favoring these kinds of trouble.

  • 0 views
  • 19 Feb, 2024
Quantifying Digital Behavior on Smart Phones - Data From Stroke Survivors

In this study, we want to continuously record the interaction of 50 stroke survivors with their smartphones during the first 3 months after discharge. The linkage of smart phone use to function and quality of life will be assessed with standardized outcome measures at defined time points.

recurrent strokes
  • 0 views
  • 19 Feb, 2024
Role of Nasal Dysbiosis in Parkinson Disease

Olfactory dysfunction is frequent in Parkinson Disease (PD) and may be present years before the motor symptoms appear. The early olfactory dysfunction could result from environmental factors acting through the nasal cavity such as microbial communities. In across-sectional bicentric study, groups of 160 PD patients and 160 controls will be …

deficit
parkinson's disease
motor symptoms
cognitive deficit
  • 0 views
  • 19 Feb, 2024
PERSONAE - a Personalized Online Treatment of Depression

The goal of this clinical trial is to determine whether a personalized online treatment for depression, delivered via an app (PERSONAE), is effective in treating mild to moderate depression in adults. The study will also assess the safety of the Monsenso app.

  • 0 views
  • 10 Aug, 2025
Determining Optimal Treatment Sequences in Anxious Depression (DOTS-AD)

Acute, double-blind, adaptively randomized treatment with duloxetine or escitalopram, followed by double-blind, randomized adjunctive treatment with clonazepam or pregabalin for persistent symptoms.

depressive disorder
nuvaring
depo-provera
depression
norplant
  • 0 views
  • 19 Feb, 2024
Mechanism of Action of Transcranial Magnetic Stimulation

This is an observational neuroimaging study assessing the effects of TMS on the brains of patients with unipolar depression.

depressive disorder
depression
psychiatric care
transcranial magnetic stimulation
major depressive disorder
  • 0 views
  • 19 Feb, 2024