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Found 203 clinical trials
Isatuximab in Combination With Lenalidomide and Dexamethasone in High-risk Smoldering Multiple Myeloma

Primary Objectives:

<ul>
  • Safety run-in: To confirm the recommended dose of isatuximab when combined with lenalidomide and dexamethasone in participants with high-risk smoldering multiple myeloma (SMM)
  • Randomized Phase 3: To demonstrate the clinical benefit of isatuximab in combination with lenalidomide and dexamethasone in the prolongation of progression-free survival when compared …

    dexamethasone
    lenalidomide
    isatuximab
    smoldering myeloma
    minimal residual disease
    • 0 views
    • 19 Feb, 2024
    • 11 locations
    Systematic Evaluation of Ablation Techniques for Non-Paroxysmal Atrial Fibrillation.

    The purpose of this study is to evaluate the safety and effectiveness of empirical posterior wall isolation (PWI), left atrial appendage electrical isolation (LAAEI) and coronary sinus isolation (CSI) when compared to pulmonary vein isolation (PVI) alone:

    <ul>
  • PVI alone,
  • PVI + PWI,
  • PVI + PWI + LAAEI,
  • PVI …

    paroxysmal atrial fibrillation
    ablation techniques
    dyspnea
    chest pain
    catheter ablation
    • 0 views
    • 19 Feb, 2024
    Long-term Safety and Efficacy Study of Fitusiran in Patients With Hemophilia A or B With or Without Inhibitory Antibodies to Factor VIII or IX

    Primary Objective:

    To characterize the long-term safety and tolerability of fitusiran

    Secondary Objectives:

    <ul>
  • To characterize the long-term efficacy of fitusiran as assessed by the frequency of:
  • Bleeding episodes
  • Spontaneous bleeding episodes
  • Target joint bleeding episodes
  • To characterize the effects of fitusiran on health-related quality of life (HRQOL) …

    haemophilia a
    hemarthrosis
    fitusiran
    antihemophilic factor
    hemophilia
    • 0 views
    • 19 Feb, 2024
    • 41 locations
    SAR408701 Versus Docetaxel in Previously Treated Carcinoembryonic Antigen-related Cell Adhesion Molecule 5 (CEACAM5) Positive Metastatic Non-squamous Non-small Cell Lung Cancer Patients

  • The primary objective is to determine whether SAR408701 improves the overall survival (OS) when compared with docetaxel in participants with metastatic non-squamous NSCLC expressing CEACAM5 2+ in intensity in at least 50% of the tumor cell population and previously treated with standard-of-care platinum-based chemotherapy and an immune checkpoint inhibitor.
    • ul>

    …

    immune checkpoint inhibitor
    non-squamous non-small cell lung cancer
    squamous non-small cell lung cancer
    docetaxel
    cancer
    • 0 views
    • 19 Feb, 2024
    • 169 locations
    Study of a Pneumococcal Conjugate Vaccine When Administered Concomitantly With Routine Pediatric Vaccines in Healthy Toddlers and Infants  

    Primary Objective:

    <ul>
  • To assess the safety profile of each SP0202 formulation and Prevnar 13 in toddlers and infants (after each and any injection).

    • 0 views
    • 19 Feb, 2024
    • 31 locations
    Study on a High-Dose Quadrivalent Influenza Vaccine Compared With Standard-Dose Quadrivalent Influenza Vaccine in Children 6 Months Through 35 Months of Age

  • To compare hemagglutination inhibition (HAI) immune response of QIV-HD to QIV-SD in participants 6 months through 35 months of age
  • To describe the HAI, seroneutralization (SN), and anti-neuraminidase (NA) immune response
  • To describe the immune response to revaccination in Season 3 (Northern Hemisphere)
  • To describe the safety profile of each …

    vaccination
    influenza
    quadrivalent inactivated influenza vaccine
    hemagglutination inhibition
    flu symptoms
    • 0 views
    • 19 Feb, 2024
    • 9 locations
    Immunogenicity and Safety Study of a Quadrivalent Meningococcal Conjugate Vaccine When Co-administered With Routine Pediatric Vaccines in Healthy Infants and Toddlers in Europe

  • To describe the safety profile of MenACYW conjugate vaccine and a licensed meningococcal vaccine.
    • ul>

    immunization schedule
    meningococcal
    renal disorders
    hepatitis b
    haemophilus
    • 0 views
    • 19 Feb, 2024
    • 29 locations
    Immunogenicity and Safety Study of a Quadrivalent Meningococcal Conjugate Vaccine When Co-administered With Routine Pediatric Vaccines in Healthy Infants and Toddlers in Europe

  • To describe the safety profile of MenACYW conjugate vaccine and a licensed meningococcal vaccine.
    • ul>

    immunization schedule
    meningococcal
    renal disorders
    hepatitis b
    haemophilus
    • 0 views
    • 19 Feb, 2024
    • 29 locations
    Asian Diabetes Outcomes Prevention Trial

    The aim of this study is to identify patients with DM at high risk of CVD using elevated N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels (>125pg/mL), and (2) intensify therapy using renin-angiotensin system (RAS) antagonists, beta-blockers and sodium glucose co-transporter-2 inhibitors (SGLT2i) for primary prevention of cardiovascular events in this high-risk …

    primary prevention
    amputation of the lower limb
    ejection fraction
    sglt2 inhibitor
    heart failure
    • 0 views
    • 19 Feb, 2024
    Angiography-Derived FFR And IVUS for Clinical Outcomes in Patients With Coronary Artery Disease

    Comparison of Angiography-derived Fractional FLow Reserve And IntraVascular Ultrasound-guided Intervention Strategy for Clinical OUtcomes in Patients with CoRonary Artery Disease

    intravascular ultrasound
    arterial disease
    heart disease
    angiography
    stenosis
    • 2 views
    • 19 Feb, 2024