Found 1376 clinical trials
Repurposing Bromocriptine for Abeta Metabolism in Alzheimer's Disease
To investigate the safety and efficacy of an orally administered dose of TW-012R in patients with Alzheimer's disease bearing PSEN1 (presenilin 1) mutations (PSEN1-AD), using a placebo group as a control. In addition, long-term safety will be examined in an open-label extension trial.
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- 19 Feb, 2024
- 7 locations
2-Hydroxybenzylamine (2-HOBA) to Prevent Early Recurrence of Atrial Fibrillation After Catheter-based Ablation
At the end of the 28-day follow-up period, study personnel will review the stored ECGs. Blood will be drawn prior to ablation and on post-procedure Day 1 for measurement of IsoLG-adduct levels. DNA will be extracted to explore a pharmacogenomic interaction with haplotypes at the chromosome 4q25 AF risk locus, …
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- 19 Feb, 2024
- 1 location
The Use of plasmaJet During Operative Laparoscopy for Endometriosis
In addition, ablation of the internal surface of endometriomas can be an effective alternative to cystectomy. The PlasmaJet system uses argon plasma which is released as kinetic, light and / or thermal energy.
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- 19 Feb, 2024
- 1 location
Study of Feasibility and Safety of UCD19 Chimeric Antigen Receptor (CAR) T Cells in Adult Subjects With Relapsed/Refractory (R/R) B-Cell Non-Hodgkin's Lymphoma (B-NHL)
This study will test whether immune cells modified to recognize B-cell non-Hodgkin lymphoma (NHL) can be successfully manufactured at the University of Colorado Anschutz and whether these cells can be administered with an acceptable safety profile.
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- 19 Feb, 2024
- 1 location
The Acute Effects of Pragmatic Manual Therapy on the Range of Motion of Shoulder Joint
Beneficial intervention among the four trials and other previously reported beneficial in improving the shoulder joint range will be combined in and termed as pragmatic interventions protocols. Pragmatic interventions on subjects with restricted range in shoulder pathology will be tested through similar design.
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- 19 Feb, 2024
- 1 location
Prone Positioning for Patients on General Medical Wards With COVID19
COVID-PRONE is a multicenter, pragmatic, single-blind, 2-arm, parallel, randomized controlled trial seeking to compare the pre-emptive prone positioning (i.e. encouraging patients to adopt a prone position before they require mechanical ventilation) to the control arm of standard care alone. Randomization will be stratified by site.
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- 19 Feb, 2024
- 7 locations
Microlearning-Based Health Education for Ambulatory Surgery Patients
Microlearning has been effective in improving knowledge and confidence in other healthcare settings, but is not yet well studied for surgical patients. A total of 50 participants will be enrolled in the study at the University Hospitals. Participants will be patients scheduled for either a mid-urethral sling procedure or a …
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- 28 Oct, 2025
- 1 location
Dynamically Tailored Behavioral Interventions in Diabetes
This study is a two-arm randomized controlled trial with n=280 participants recruited from the participating Federally Qualified Health Centers (FQHCs). The participants will be randomly assigned to the intervention group and the usual care (control) group with 1-1 allocation ratio. Half of the participants (n=140) will be randomly assigned to …
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- 19 Feb, 2024
- 2 locations
BCI-FES Therapy for Stroke Rehabilitation
When BCI systems are integrated with functional electrical stimulation (FES) systems, they can be used to deliver a novel physical therapy to improve movement after stroke. BCI-FES systems are hypothesized to stimulate recovery after stroke beyond that of conventional physical therapy.
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- 19 Feb, 2024
- 1 location
Spermatogonial Stem Cell (SSC) Transplant and Testicular Tissue Grafting
Spermatogonial stem cell transplantation through ultrasound guided rete testis injection and testicular tissue grafting will be performed for participants who have frozen testicular tissue prior to gonadotoxic therapy. The purpose of this study is to test the safety and feasibility of these transplant technologies and restore fertility for these participants.
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- 19 Feb, 2024
- 1 location