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Found 219 clinical trials
Study on Biomarkers of Periodontitis and Type 2 Diabetes Mellitus in Males and Females 30 - 70 Years of Age

Participants will be categorized based on point-of-care hemoglobin A1c (HbA1c) and periodontal disease (PD) staging into 9 subgroups. The key objectives of the study are:

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  • To evaluate immune signatures in well-characterized populations with or without PD and/or T2DM
  • To evaluate baseline clinical biomarkers of T2DM and PD in well-characterized populations
  • To evaluate the …

    Accepts healthy volunteers
    • 0 views
    • 14 May, 2025
    A Study to Evaluate the Safety Tolerability and Pharmacokinetics of Orally Inhaled Aerosolized Hydroxychloroquine Sulfate in Healthy Adult Volunteers

  • To determine the recommended Phase 2a dose (RP2D).
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    Secondary objectives:

    To characterize pharmacokinetics (PK) of single dose AHCQ in healthy individuals.

    immunodeficiency
    oral contraceptives
    hydroxychloroquine
    oropharyngeal
    bilateral oophorectomy
    • 0 views
    • 19 Feb, 2024
    A Study of Subcutaneous Risankizumab Injection for Pediatric Participants With Moderate to Severe Plaque Psoriasis to Assess Change in Disease Symptoms

    Part 2: Participants aged 12 < 18 will receive;

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  • Period A: Risankizumab or ustekinumab based on body weight followed by;
  • Period B: Risankizumab or no treatment.

    ustekinumab
    plaque psoriasis
    psoriasis
    inflammatory disease
    blood tests
    • 0 views
    • 19 Feb, 2024
    A Study on the Safety and Immunogenicity of Influenza, Respiratory Syncytial Virus, Human Metapneumovirus and Parainfluenza Vaccines in Adults 18 to 49 Years of Age.

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    Participants will be provided with a diary to solicit reporting of injection site reactions and systemic reactions, unsolicited Adverse Events (AEs), Serious Adverse Events (SAEs) and Adverse Events of Special Interest AESIs).

    Accepts healthy volunteers
    • 0 views
    • 08 May, 2025
    Mobility Protocol Adapted for Advanced Visually Impaired Subjects

    People Retinitis Pigmentosa therefore encounter a large number of difficulties in daily life, specifically for:

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  • Visual research
  • Visuo-motor coordination in tasks requiring fine motor control
  • Visuo-motor coordination in mobility tasks
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    This study aims to assess the difficulties in the daily life of subjects with …

    low vision
    amblyopia
    cognitive disorders
    retinitis
    visual impairment
    • 0 views
    • 19 Feb, 2024
    Innovating Access to Novel Therapies Through Standardized Prospective Integration of Response Evaluations (IMPACT-INSPIRE) (IMPACT-INSPIRE)

  • To demonstrate that it is feasible to standardize investigations and endpoints in this proof-of-concept study.

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  • Through standard safety laboratory investigations (FBC, U/E/Cr, LFT)
  • Through standard radiological imaging at 6-12 weeks with the key endpoint being best response during that imaging window, and disease control rate at 6 months.

    • 0 views
    • 07 May, 2025
    Avelumab and Methotrexate in in Low-risk Gestational Trophoblastic Neoplasias as First Line Treatment

  • Cytotoxicity of avelumab is mediated through antibody dependent cell cytotoxicity (ADCC) by NK cells.
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    • 0 views
    • 19 Feb, 2024
    • 0 views
    • 26 Sep, 2024
    • 1 location
    change - Safety and Tolerability of TOP-N53 Applied on Digital Ulcers in Patients With Systemic Sclerosis (TOP-N53-02)  

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    Researchers will compare TOP-N53 solution in different strengths to a placebo (a look-alike substance that contains no drug) to see if TOP-N53 works to affect the aspects of the illness listed above.

    • 0 views
    • 13 Jun, 2025
    • 2 locations
    Safety and Tolerability of TOP-N53 Applied on Digital Ulcers in Patients With Systemic Sclerosis (TOP-N53-02)  

    ul>

    Researchers will compare TOP-N53 solution in different strengths to a placebo (a look-alike substance that contains no drug) to see if TOP-N53 works to affect the aspects of the illness listed above.

    • 0 views
    • 28 May, 2025