Found 1247 clinical trials
Safety and Immunogenicity Study of GX-19 a COVID-19 Preventive DNA Vaccine in Healthy Adults
The objective of our study is to evaluate safety, tolerability, and immunogenicity of COVID-19 preventive DNA vaccine in healthy volunteers.
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- 19 Feb, 2024
- 1 location
Effects of Pau d' Arco in Primary Dysmenorrhea
A single arm, open-label trial evaluating safety and tolerability of encapsulated Tabebuia avellanedae in 12 generally healthy women aged 18-45 with primary dysmenorrhea (PDM). This will be the first study evaluating the safety and tolerability of Tabebuia avellanedae in PDM. We also aim to collect proof-of-concept mechanistic data supporting the …
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- 19 Feb, 2024
- 1 location
Comparison of Tofacitinib and Methotrexate in Takayasu's Arteritis
The aim of this study is to evaluate and compare the efficacy and safety of tofacitinib and methotrexate based on prednisone therapy in patients with Takayasu arteritis
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- 19 Feb, 2024
- 1 location
A Study of ADRX-0405 in Subjects with Select Advanced Solid Tumors
The primary purpose of this study is to assess the safety, tolerability, and pharmacokinetics, and to identify the optimal dose of ADRX-0405 in patients with select advanced solid tumors.
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- 13 May, 2025
- 3 locations
Cyclosporine in Patients With Moderate COVID-19
Phase 1 safety study to determine the tolerability, clinical effects, and changes in laboratory parameters of short course oral or IV cyclosporine (CSA) administration in patients with COVID-19 disease requiring oxygen supplementation but not requiring ventilator support.
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- 19 Feb, 2024
- 1 location
Cardiometabolic Effects of Rapid Glucose Excursion
The effects of rapid glucose excursions, induced by intravenous bolus application of glucose in healthy probands, on cardiometabolic and inflammatory parameters will be investigated
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- 19 Feb, 2024
- 1 location
UAB Alzheimer's Disease Center Core Cohort - Imaging Substudy
The primary objective of this study is to measure the concentration and the regional brain distribution of pathologic amyloid deposition using the PET tracer [C-11]PiB in participants in the UAB Alzheimer's Disease Center cohort. Assessment of interactions between race and vascular risk factors, brain amyloid levels measured with [C-11]PiB-PET, and …
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- 19 Feb, 2024
- 1 location
Metformin for Abdominal Aortic Aneurysm Growth Inhibition
A multi-centre population-based open-label randomized controlled trial with allocation concealment and blinded outcome assessment will examine if up to 2g metformin daily slows AAA growth in patients with small AAAs who do not have diabetes.
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- 19 Feb, 2024
- 1 location
Histopathologic Effect of Calcium Electroporation on Cancer in the Skin
In this phase II study we investigate the effect of calcium electroporation on cancer in the skin investigated by histopathology.
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- 19 Feb, 2024
- 1 location
Hypofractionated Radiotherapy in Elderly Patients With Head & Neck Squamous Cell Carcinoma
The purpose of this research study is to investigate a shorter radiation treatment schedule for head and neck cancers in patients 70 years of age and older. Standard radiation treatment for head and neck patients normally requires that the patient travel to the hospital daily for 6-7 weeks to receive …
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- 19 Feb, 2024
- 4 locations