castration-resistant prostate cancer Clinical Research Trials

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Found 368 clinical trials

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Phase 1
For Seniors
For adults
Recruiting in 10s
Interventional Study
For Males
Recruiting

A Study of Copanlisib Combined With Rucaparib in Patients With Metastatic Castration-resistant Prostate Cancer

This is a single arm Phase Ib/II, open label, safety, pharmacokinetic and efficacy clinical study in adult patients with metastatic castration-resistant prostate cancer (mCRPC). Patients will be treated with the combination of copanlisib and rucaparib for as long as the patient does not have clinically significant progressive disease and/or unacceptable …

liver metastasis

BRCA1

lipase

psa level

androgen suppression

0 views
19 Feb, 2024
1 location

For Seniors
For adults
Recruiting in 10s
Interventional Study
For Males
Recruiting

Metastasis-directed Therapy in Castration-refractory Prostate Cancer

The aim is to define the postponement of next line systemic treatment (NEST), by the use of metastasis-directed therapy in patients with oligoprogressive castration-refractory prostate cancer. This will be defined by the NEST-free survival. Furthermore the investigators will use 18F PSMA PET-CT as investigational imaging, to assess the predictive value …

bone scan

testosterone

PET-CT

metastasectomy

metastasis

0 views
19 Feb, 2024
1 location

Includes pre-screening
Phase 1
Recruiting in 10s
Interventional Study
all
Recruiting

A Study of ADRX-0405 in Subjects with Select Advanced Solid Tumors

The primary purpose of this study is to assess the safety, tolerability, and pharmacokinetics, and to identify the optimal dose of ADRX-0405 in patients with select advanced solid tumors.

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13 May, 2025
3 locations