Found 1264 clinical trials
89Zr-atezolizumab PET Scan and Lobular Breast Cancer
The exploratory single center feasibility ImaGelato study is conducted as an imaging side study to the Dutch GELATO trial (Assessing efficacy of carboplatin and atezolizumab in metastatic lobular breast cancer).
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- 19 Feb, 2024
- 1 location
Backpack Weight Impacts
The base pack weight (BPW) includes gear that is not consumed or worn on the body: shelter, sleep system, weather-proofing layers and personal gear to ensure a degree of comfort and safety. As such, reducing BPW is one of the most important tasks a backpacker manages when preparing for a …
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- 19 Feb, 2024
- 1 location
Efficacy of Near-Infrared Vein Imaging for Difficult IV Placement
The investigators hypothesize that the capability to successfully place lasting peripheral venous catheters is increased with the adjunct of the imaging technology, reducing the number of failed needle sticks, reducing the number of peripheral venous catheters placed throughout a patient's hospital stay, and reducing the need for more invasive catheters …
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- 19 Feb, 2024
- 1 location
Study to Assess Disease Activity and Biomarkers in Minority Participants With Relapsing Multiple Sclerosis (RMS) Before and During Treatment With Ocrelizumab
The treating neurologist must make an independent medical assessment and decision to initiate ocrelizumab treatment per label (USPI) as the most appropriate standard of care treatment for the participant. 150 participants will be enrolled in the main study (75 AA and 75 HA) and 50 participants will be enrolled in …
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- 19 Feb, 2024
- 31 locations
Effect of Glucose 5% on Labor Length
However, the addition of glucose supplementation to this IV hydration to enhance uterine contraction, as a matter of safety and efficacy, is controversial
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- 19 Feb, 2024
- 1 location
Effect of the Postbiotics on Complications Treatment in Elderly Hemodialysis Patients
Researchers will analyze the change of indicators such as quality of life and nutrition state of participants from the baseline to end of treatment, and compare the difference between the two group.
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- 16 May, 2025
The Restoration of Endodontically Treated Teeth Using Indirect Full Coverage Restorations Compared to Direct Composite Resin Restorations
A more conservative treatment option could be selected for a root treated tooth with good amount of remaining tooth structure such as direct restorations. The aims of this randomized clinical trial is to compare the survival and success of root treated teeth with occlusal cavities and at least three intact …
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- 19 Feb, 2024
- 1 location
NUVOLA TRIAL Open-label Multicentre Study
Preclinical data suggest that olaparib might also potentiate the efficacy of DNA-damaging chemotherapies, including platinum-containing drugs such as carboplatin. In a recent phase Ib/II study, olaparib plus weekly carboplatin and paclitaxel in relapsed ovarian cancer patients was shown to be safe, well tolerated and effective, especially in germline BRCA mutated …
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- 19 Feb, 2024
- 1 location
Diffusion MRI for Head and Neck Cancer
However, it is often underappreciated that these dMRI metrics are not fixed constants, but rather functions of the diffusion time t, D(t) and K(t); their t-dependency is determined by tissue properties, such as cell size and membrane permeability of tissue. D(t) and K(t) of tumors can vary substantially depending on …
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- 19 Feb, 2024
- 1 location
Patients With ES-SCLC and ECOG PS=2 Receiving Atezolizumab-Carboplatin-Etoposide
Between 14 and 23% of SCLC patients develop brain metastases. New cytotoxic agents as well as targeted therapies have not been able to show any improvement of survival in this group of patients. Early phase trials of PD 1/PD L1-blocking immunotherapeutic agents in patients with recurrent or ED SCLC have …
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- 19 Feb, 2024
- 1 location