hereditary cancer syndromes Clinical Research Trials

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Found 262 clinical trials

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Phase 1
For pediatric ages
For adults
Recruiting in 10s
Interventional Study
all
Dermatology
Recruiting

B7H3 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults

This is a phase I, open-label, non-randomized study that will enroll pediatric and young adult research participants with relapsed or refractory non-CNS solid tumors to evaluate the safety, feasibility, and efficacy of administering T cell products derived from the research participant's blood that have been genetically modified to express a …

iobenguane

biological therapy

cytokine release syndrome

systemic corticosteroid therapy

steroid therapy

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19 Feb, 2024

Phase 2
For pediatric ages
For adults
Recruiting in 10s
Interventional Study
all
Endocrinology
Recruiting

Tipifarnib for the Treatment of Advanced Solid Tumors Lymphoma or Histiocytic Disorders With HRAS Gene Alterations a Pediatric MATCH Treatment Trial

This phase II pediatric MATCH trial studies how well tipifarnib works in treating patients with solid tumors that have spread to other places in the body (advanced), lymphoma, or histiocytic disorders that have HRAS genetic alterations. Tipifarnib may block the growth of cancer cells that have specific genetic changes in …

recurrent ewing sarcoma

measurable disease

neutrophil count

bone marrow procedure

cytokines

0 views
19 Feb, 2024

For pediatric ages
For adults
Recruiting in 1000s
Observational Study
all
Endocrinology
Recruiting

Therapeutic Recommendations for Nephroblastoma

The study is based on results form 2 previous studies carried out by the GFAOP. The aim of this study is to evaluate the capacity of units to follow the recommendations in the protocol.

wilms' tumour / nephroblastoma

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19 Feb, 2024