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Found 257 clinical trials
A Study of CC-98633 BCMA-targeted Chimeric Antigen Receptor (CAR) T Cells in Subjects With Relapsed and/or Refractory Multiple Myeloma

The dose-escalation part (Part A) of the study is to evaluate the safety and tolerability of increasing dose levels of CC-98633 to establish a recommended Phase 2 dose (RP2D); and the dose-expansion part (Part B) of the study is to further evaluate the safety, pharmacokinetics/pharmacodynamics, and efficacy of CC-98633 at …

bcma
refractory multiple myeloma
ixazomib
bortezomib
lenalidomide
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  • 19 Feb, 2024
Study to Evaluate the Safety Tolerability Pharmacokinetics and Pharmacodynamics of CC-94676 in Subjects With Metastatic Castration-Resistant Prostate Cancer

This is a first in human study to assess the safety, tolerability, PK, PD and preliminary efficacy of CC-94676 in men with progressive metastatic castration-resistant prostate cancer.

metastatic castration-resistant prostate cancer
adenocarcinoma of prostate
bilateral orchidectomy
gonadotropin
androgen suppression
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  • 19 Feb, 2024
Codman Catheter/Synchromed Pump Hepatic Artery Chemotherapy for Unresectable Colorectal Metastases/Intrahepatic Cholangiocarcinoma

This study aims to test the safety of hepatic artery infusion pump placement, a standard surgical procedure, and intraarterial chemotherapy initiation with the standard medication floxuridine (FUDR), using the Medtronic Synchromed II pump combined with the Codman arterial catheter in patients with unresectable (not removable by surgery) liver metastases from …

liver metastasis
dexamethasone
hepatic arterial infusion
neutrophil count
metastatic adenocarcinoma
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  • 19 Feb, 2024
Adaptative MR-Guided Stereotactic Body Radiotherapy of Liver Tumors

Stereotactic radiotherapy is a recent technique proposed to hepatic metastases treatment from solid cancers and primary hepatic lesions (HCC or cholangiocarcinomas); it is possible to deliver high doses of radiation in the most conformational way possible in order to limit the irradiation of the non-tumor liver.

chelates
hepatitis
metastasis
liver diseases
stereotactic radiation therapy
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  • 19 Feb, 2024
Diagnosis Treatment Status and Prognosis of Cholangiocarcinoma in China: a Multicenter Two-way Non-intervention Study

This is a multicenter, two-way, non-intervention study. the main purpose: Understand the current status of diagnosis and treatment of cholangiocarcinoma patients in China and observe the effect of different treatment options on patient recurrence and long-term survival Secondary purpose: Exploring the actual clinical treatment situation and its compliance with the …

cancer
cholangiocarcinoma
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  • 19 Feb, 2024
PROtocol of Metabolic and Cryptogenic livEr Disease regisTry for intEgration of Omic Studies

The main aim of the study is to set up an observational cohort with NAFLD (Non-alcoholic fatty liver disease) at different stage of disease (from simple steatosis to cirrhosis and/or HCC-Hepatocellular carcinoma) and for comparative purpose a cohort of subjects with diabetes and/or obesity and/or other risk factors (i.e. psoriasis, …

hcv infection
biopsy of liver
psoriasis
hepatocellular carcinoma
hepatitis c
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  • 19 Feb, 2024
Non Exudative AMD Imaged With SS-OCT- Extension

The investigators wish to better understand the role of the choriocapillaris (CC) in the formation and progression of non-exudative in age related macular degeneration (armd) by imaging the retinal pigment epithelium (rpe) and the choroidal microvasculature and by studying their inter-dependence to determine if the loss of the CC could …

retinal pigment
drug trials
age-related macular degeneration
maculopathy
macular degeneration
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  • 19 Feb, 2024