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Found 241 clinical trials
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Fiber Metabolism in Chronic Obstructive Pulmonary Disease

The impact of fiber intake on short chain fatty acid (SCFA) metabolism has not been studied in subjects suffering from COPD. The purpose of this study is to compare changes in SCFA metabolism after inulin vs. placebo intake in COPD patients to healthy matched controls. This protocol is an extension …

lung disorder
pulmonary disease
  • 0 views
  • 19 Feb, 2024
Hyperpolarized Imaging for New Treatments

The introduction of triple combination CFTR modulator therapy for patients with Cystic Fibrosis (CF) with at least one copy of the deltaF508 mutation is expected to provide major health benefits, but will also require novel outcome measures that can detect CF lung disease at an early stage, capture the efficacy …

multiple breath washout
sweat chloride test
pulmonary disease
antibiotic therapy
fibrosis
  • 0 views
  • 19 Feb, 2024
Connexin Genotypes in Cystic Fibrosis

Methods:Patients homozygous for delta F508 get recruited from the CF centres of Bonn, Frankfurt and Amsterdam. Sequence analysis is performed for connexin 43 and 37. Clinical disease is assessed longitudinally over 3 years by pulmonary function tests (FEV1 (forced expiratory volume in one second), FVC (=(forced vital capacity), FEF75 % …

pulmonary disease
fibrosis
diabetes
prednisone
cystic fibrosis
  • 0 views
  • 19 Feb, 2024