Found 1376 clinical trials
Neoadjuvant Chemoradiotherapy Combined With Perioperative Toripalimab in Locally Advanced Esophageal Cancer
How to improve the the efficacy of neoadjuvant therapy is an important clinical problem to be solved. Immunotherapy targeting the PD-1/PD-L1 checkpoints has demonstrated promising activity in advanced EC especially in ESCC.
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- 19 Feb, 2024
- 1 location
Immunity and Safety of Covid-19 Synthetic Minigene Vaccine
In this study, the safety and efficacy of this LV vaccine (LV-SMENP) will be investigated.
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- 19 Feb, 2024
- 3 locations
Effects of Brain Stimulation on Cognition Oscillations and GABA Levels in Schizophrenia
Behavioral, electrophysiological (EEG) and neuroimaging measures will be used to assess cognitive performance. This study has three main goals: (1) To compare the effects of task-engaged versus resting tDCS in order to optimize the impact of tDCS on goal maintenance related neural oscillatory activity and task performance in schizophrenia; (2) …
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- 19 Feb, 2024
- 1 location
Pelvic Floor Magnetic Stimulation in Women With Idiopathic Overactive Bladder
Moreover, there is no recommendation on conservative treament combinations in the guidelines due to insufficient data. At this stage, studies are needed to determine whether it will be effective to use MS in combination with other conservative treatment options. In addition, in the light of our clinical experience, we think …
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- 19 Feb, 2024
- 1 location
Microbiota and Bone Fragility:Study of the Relation Between Gut Microbiota and Bone Microarchitecture
The investigators will compare gut microbiota composition in four groups of women aged 60 recruited on the basis of bone mineral density (BMD) and personal history of fracture. the participants will have diagnostic exams: clinical tests, bone densitometry (body composition, vertebral fractures), high resolution peripheral QCT (bone strength estimated by …
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- 19 Feb, 2024
- 1 location
Carotid Doppler and EEOT for Fluid Responsiveness Prediction
Carotid doppler is a non-invasive, bedside, easy to use ultrasound technique that measuring blood flow peak velocity (CDPV) and duration of systolic component of each cardiac cycle (from the onset to dicrotic notch- Flow time - FT) allows a reliable estimation of fluid status and could be an interesting alternative …
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- 19 Feb, 2024
- 1 location
Morphological Parameters of In-stent RESTenosis Assessed and Identified by OCT
The investigators propose a prospective, multicentre study of all cases of intrastent restenosis, examined by angiography, causing clinical features involving stable angina and acute coronary syndrome. The coronary artery involved will be routinely studied by OCT for a mechanical cause of the intrastent restenosis. The routine use of intrastent OCT …
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- 19 Feb, 2024
- 1 location
Tissue-engineered Skin Graft Repair of Autologous Scar Dermal Scaffolds
It affects the appearance and some scar contracture often leads to joint dysfunction.Patients have low quality of life, long treatment cycle, heavy social burden and high medical costs.Skin grafting is currently the gold standard for scar repair.However, there are often insufficient skin sources, easy to scar recurrence, lack of skin …
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- 19 Feb, 2024
- 1 location
CAD/CAM Fixed Retainers vs. Conventional Multistranded Fixed Retainers in Orthodontic Patients. Comparison of Stability Retainer Failure Rate Adverse Effects Cost-effectiveness and Patient Satisfaction. A Randomized Controlled Clinical Trial
There are different types of retainers, some are fixed (glued to the back of the front teeth), and others are removable (can be removed and replaced into the mouth by the patient). While there are various retainers used for retention (stability), there is no perfect method.
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- 19 Feb, 2024
- 1 location
Patients With ES-SCLC and ECOG PS=2 Receiving Atezolizumab-Carboplatin-Etoposide
The investigators expect, that atezolizumab in addition to chemotherapy is feasible in patients with stage IV SCLC and reduced performance status and therefore crucial efficacy data can be acquired in this trial to evaluate a putative Phase III transition in this particular patient population.
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- 19 Feb, 2024
- 1 location