Found 21 clinical trials
Early Environmental and Maternal Determinants of Airway Inflammation in Wheezing Disorders in Infants
This study collects data on microbiological, genetic and environmental factors, as well as lung function parameters (e.g. spirometry, body plethysmography, lung-MRI) to assess the complex interaction of predisposing risk factors for impaired lung development and respiratory diseases.
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- 19 Feb, 2024
- 1 location
Gut Microbiota and Alzheimer's Diseases
The investigator will perform clinical studies to test the hypothsis that participants who had Alzhemer's disease will have different gut microbiota in the feaces as compared to participants who did not have Alzhemer's disease, as well as compared to their spouse.The investigators plan to perfoem the studies in 150 participants …
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- 20 Sep, 2024
- 1 location
Intestinal Flora Research Plan for Critically Ill Patients
These studies have uncovered the changes and impacts of intestinal microbiota in critically ill patients in ICU, but they are still in the stage of touching the image of blind people. The relevant mechanisms and dynamic changes and their significance are unclear, requiring large-scale, dynamic, continuous and comprehensive In order …
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- 19 Feb, 2024
- 1 location
Role of Nasal Dysbiosis in Parkinson Disease
In across-sectional bicentric study, groups of 160 PD patients and 160 controls will be compared for nasal microbiota composition according to their geographical origin. We will search an association between microbiota and the presence of an olfactory deficit, cognitive deficit and thymic disorder.
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- 19 Feb, 2024
- 2 locations
Development of Systems and Precision Medicine - Take Mood Disorder as an Example.
In this three-year proposal, we explore the interactions of genetic variants and environmental factors (represented by psychosocial stress and gut microbiota) driven approaches to develop precision medicine.
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- 19 Feb, 2024
- 1 location
Clinical and Molecular Study of Endometriosis and Adenomyosis
We also aimed to address molecular questions on immune dialogues between ectopic lesions and the eutopic endometrium, auto-immunity in endometriosis and adenomyosis and the role of the microbiota in their respective pathophysiologies.
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- 19 Feb, 2024
- 1 location
Trajectory of Microbiota Maturation in Healthy Bern Infants - a Network Approach
Background: Intestinal microbiota composition is fundamental to human health and undergoes critical changes within the first two years of life. Factors probably influencing the microbiota are the maternal microbiota and the general environment in Switzerland.
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- 19 Feb, 2024
- 1 location
Microbiota in COVID-19 Patients for Future Therapeutic and Preventive Approaches
To establish colonization, pathogens have to interact with the local microbiota (a.k.a. microbiome) and certain microbiome profiles will be more resistant to pathogen invasion. Finally, (III) Handheld devices used in clinical routine are a potential reservoir and carrier of both, SARS-CoV-2, as well as bacteria causing nosocomial pneumonia.
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- 19 Feb, 2024
- 1 location
Gut Microbiota SCFAs and Glucolipid Metabolism in Pregnant Women With Abnormal Fetal Size and Their Newborns
Studies have found that gut microbiota can regulate insulin sensitivity and glucose and lipid metabolism disorders through SCFAs. Therefore, this research group uses the gut microbiota as a new idea to studythe relationship of gut microbiota characteristics and level's change of SCFAs with glucolipid metabolism and insulin sensitivity in pregnant …
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- 19 Feb, 2024
- 1 location
Epidemiological Study of the Microbiota in Critically Ill Children (n=100) From 1 to 16 Years Compared With Healthy Controls (n=50) and Its Relationship With Clinical Complications and Inflammatory Biomarkers
Objectives: To study the composition of the microbiota in critically ill children, and to know the relationship of its microbiota with clinical complications and inflammation biomarkers.
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- 19 Feb, 2024
- 1 location