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Found 223 clinical trials
Determination of the Optimal Treatment Target in Ulcerative Colitis

Participants with active UC will be randomized in a 2:3:5 ratio to 1 of 3 groups, each with a different treatment target. Treatment targets will be defined as:

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  • Group 1: corticosteroid-free symptomatic remission
  • Group 2: corticosteroid-free endoscopic + symptomatic remission
  • Group 3: corticosteroid-free histological + endoscopic …

    corticosteroids
    colitis
    hepatitis b
    remission
    ulcerative colitis
    • 0 views
    • 19 Feb, 2024
    Study of Lunsekimig (SAR443765) Compared With Placebo in Adults With High-risk Asthma (AIRLYMPUS)

  • The investigational treatment duration will be up to approximately 52 weeks.
  • The number of visits will be 18.
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    • 0 views
    • 15 May, 2025
    A Study to Evaluate the Efficacy and Safety of JCAR017 in Adult Subjects With Relapsed or Refractory Indolent B-cell Non-Hodgkin Lymphoma (NHL)

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    cyclophosphamide
    systemic therapy
    follicular lymphoma
    b-cell lymphoma
    hodgkin's disease
    • 0 views
    • 19 Feb, 2024
    A Phase 3 Study to Assess the Efficacy, Safety, and Tolerability of Itepekimab (Anti-IL-33 mAb) in Participants With Inadequately-controlled Chronic Rhinosinusitis With Nasal Polyps (CEREN2)

  • The number of visits will be 9 site visits and 20 phone/home visits.
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    • 0 views
    • 02 Jun, 2025
    SAR439859 Plus Palbociclib as First Line Therapy for Patients With ER(+) HER2(-) Advanced Breast Cancer

    Primary Objective:

    To determine whether SAR439859 in combination with palbociclib improves progression free survival (PFS) when compared with letrozole in combination with palbociclib in participants with ER+, HER2- advanced breast cancer who have not received any prior systemic anticancer therapies for advanced disease.

    Secondary Objective:

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  • To compare …

    palbociclib
    her2-negative breast cancer
    breast cancer
    HER2
    solid tumors
    • 0 views
    • 19 Feb, 2024
    • 5 locations
    Phase 2 Study of SAR439859 Versus Physician's Choice in Locally Advanced or Metastatic ER-positive Breast Cancer (AMEERA-3)

  • To compare the overall safety profile in the 2 treatment arms.
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    estrogen receptor
    breast cancer
    oestrogen receptor positive breast cancer
    HER2
    ESR1
    • 0 views
    • 19 Feb, 2024
    • 126 locations
    Efficacy and Safety Study of Frexalimab (SAR441344) in Adults With Nonrelapsing Secondary Progressive Multiple Sclerosis (FREVIVA)  

  • The number of scheduled visits will be up to 27 (including 3 follow-up visits) with a visit frequency of every month for the first 6 months and then every 3 months.
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    • 0 views
    • 04 Mar, 2025
    A Medical Research Study Designed to Determine if Venglustat Can be a Future Treatment for ADPKD Patients

  • To evaluate the effect of venglustat on the lens by ophthalmological examination (Stages 1 and 2).
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    cystic renal diseases
    autosomal dominant
    human chorionic gonadotropin
    fatigue
    depression
    • 0 views
    • 19 Feb, 2024
    • 81 locations
    Study of a Novel Multicomponent Meningococcal Group B Vaccine When Given Alone or With Other Licensed Vaccines in Adults, Adolescents, Toddlers and Infants

    Primary Objective:

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  • To describe the safety profile of the SP MenB vaccine formulations and the 2 licensed MenB comparator vaccines in healthy adults, adolescents, toddlers and infants, when administered alone (Stages 1-4) or concomitantly with MenQuadfiTM (MenACYW conjugate vaccine) (for Stages 2-4 only), and with age-appropriated routine pediatric vaccines …

    Accepts healthy volunteers
    • 0 views
    • 19 Feb, 2024
    • 22 locations
    Study of a Novel Multicomponent Meningococcal Group B Vaccine When Given Alone or With Other Licensed Vaccines in Adults, Adolescents, Toddlers and Infants

    Primary Objective:
    <ul>
  • To describe the safety profile of the SP MenB vaccine formulations and the 2 licensed MenB comparator vaccines in healthy adults, adolescents, toddlers and infants, when administered alone (Stages 1-4) or concomitantly with MenQuadfiTM (MenACYW conjugate vaccine) (for Stages 2-4 only), and with age-appropriated routine pediatric vaccines …

    Accepts healthy volunteers
    • 0 views
    • 19 Feb, 2024
    • 21 locations