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Found 267 clinical trials
Effect of Cannula Size on Oxygen Saturation During Nasal High Flow Therapy in Newborns

Treatment with nasal high flow therapy (NHF) is an increasingly popular method of respiratory support in newborns. Safe and effective use of NHF requires selection of an appropriate nasal prong-to-nares ratio because leak can influence the delivered pressure. To the best of our knowledge, this is the first study to …

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  • 19 Feb, 2024
Carrimycin in Patients With Locally Advanced Recurrent or Metastatic HNSCC (Non NPC): A Phase I Trial

The trial is a study conducted to evaluate the safety, tolerability and PK characteristics of Carrimycin tablet and measure its anti-tumor efficacy initially in the treatment of patients with locally advanced, recurrent, or metastatic head and neck squamous cell carcinoma (non NPC).

squamous cell carcinoma of head and neck
aptt
metastatic head and neck squamous cell carcinoma
squamous cell carcinoma
metastatic head and neck squamous cell cancer
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  • 19 Feb, 2024
A Study of BPI-1178 in Patients With Advanced Solid Tumor and HR+/HER2- Breast Cancer

BPI-1178 is a novel, orally administered inhibitor of both cyclin-dependent kinase 4CDK4and CDK6 kinase activity. The purpose of this study is to evaluate the safety, efficacy and pharmacokinetics of BPI-1178 in subjects with advanced solid tumor, as well as the subjects with advanced hormone receptor-positive(HR+)/human epidermal growth factor receptor 2 …

thromboplastin
human epidermal growth factor
her2/neu-negative breast cancer
gilbert's syndrome
absolute neutrophil count
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  • 19 Feb, 2024
An Avatar-based Mobile Phone Intervention to Promote Health in African American MSM

The investigators propose to determine the efficacy of "My Personal Health Guide," a theory-based innovative talking relational human Avatar mobile phone application to engage HIV-positive AAMSM in adherence and retention in care. Providing an empathetic talking Avatar source of HIV-related information, motivation, and behavioral skills that is as private and …

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  • 19 Feb, 2024
Prone Positioning for Patients on General Medical Wards With COVID19

COVID-PRONE is a multicenter, pragmatic, single-blind, 2-arm, parallel, randomized controlled trial seeking to compare the pre-emptive prone positioning (i.e. encouraging patients to adopt a prone position before they require mechanical ventilation) to the control arm of standard care alone. Randomization will be stratified by site.

mechanical ventilation
covid-19
fraction of inspired oxygen (fio2)
FIO2
nosocomial infection
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  • 19 Feb, 2024
Comparison of Karydakis and Limberg Flap Treatment of Pilonidal Sinus in Adolescent. a Prospective Randomised Study

Pilonidal sinus disease (PSD) is a chronic inflammation and infection of the sacrococcygeal region. Produces clinic findings with abscess and discharge in the sacrococcygeal region or painful sinus tract in the natal cleft. Its incidence rate among Turkish servicemen is reported to be 8.8% in a study. Although pilonidal sinus …

pilonidal sinus
sinus disease
chronic inflammation
abscess
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  • 19 Feb, 2024
Dupilumab for the Treatment of Moderate to Severe Chronic Hepatic Pruritus

To investigate the potential efficacy of dupilumab in the treatment of moderate to severe chronic hepatic pruritus.

dupilumab
chronic pruritus
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  • 19 Feb, 2024
PB2452 in Ticagrelor-treated Patients With Uncontrolled Major or Life-Threatening Bleeding or Requiring Urgent Surgery or Invasive Procedure

This is a multi-center, open-label, prospective single-arm study of reversal of the antiplatelet effects of ticagrelor with PB2452 in patients who present with uncontrolled major or life-threatening bleeding or who require urgent surgery or invasive procedure. Approximately 200 patients will be enrolled at approximately 200 centers worldwide. Patients with reported …

coronary artery bypass graft
heart surgery
orthopedic surgery
systolic blood pressure
blood transfusion
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  • 19 Feb, 2024
Irreversible Electroporation of Unresectable Liver Tumors

The aim of this study is to evaluate the safety and feasibility of curative intended irreversible electroporation (IRE) in the treatment of liver tumors neighboring major vessels or bile ducts.

liver tumor
biliary tract cancer
hepatoma
irreversible electroporation
cancer
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  • 19 Feb, 2024
Strength for U in Relationship Empowerment

The objective of this study is to test whether the innovative intervention, "Strength for U in Relationship Empowerment" (SURE), reduces the frequency of IPV more than an attention, time, and information matched control condition in perinatal women seeking mental health care.

drug use
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  • 19 Feb, 2024