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Found 479 clinical trials
Efficacy of Different Toothbrushes and Hygiene Regimen

Two calibrated and blinded examiners (Cohen Kappa 85%) will evaluate the gingival condition using the visible plaque indices, a simplified oral hygiene index - IHOS and gingival bleeding index, with the aid of a WHO probe. For the evaluation of halitosis levels, all individuals will respond to a questionnaire regarding …

colgate
cavity
halitosis
plax mouthwash
gingivitis
  • 0 views
  • 19 Feb, 2024
Ketamine Analgesia in Third Molar Surgery

New knowledge of the mechanisms of pain increases the opportunities for individual and safe pain relief. Day case surgery is performed in all operating specialties, this might affects many patients nationally and internationally.

postoperative pain
local anesthesia
systemic disease
morphine
acute pain
  • 0 views
  • 19 Feb, 2024
Personalized Extended Interval Dosing of Natalizumab in Relapsing Remitting Multiple Sclerosis

Study design: Prospective national phase IV natalizumab cohort study. Study population: All patients, aged 18 years or older, who are currently treated with natalizumab in the Netherlands for RRMS, with a minimum of 6 consecutive infusions.

extended interval dosing
white matter disease
multiple sclerosis
progressive multifocal leukoencephalopathy
relapsing multiple sclerosis
  • 0 views
  • 19 Feb, 2024
Bintrafusp Alfa in Previously Treated Patients With Recurrent and Metastatic (R/M) Non-keratinizing Nasopharyngeal Carcinoma (NPC)

This would be a phase II prospective single arm mono-institutional study conducted in Queen Mary Hospital (Hong Kong) assessing the efficacy and safety of bintrafusp alfa in previously treated patients with recurrent and metastatic (R/M) non-keratinizing nasopharyngeal carcinoma (NPC).

serum total bilirubin level
adjuvant therapy
serum total bilirubin
immunomodulators
measurable disease
  • 0 views
  • 19 Feb, 2024
ICG vs. HSI in Gastrointestinal Resections

In this study, gastrointestinal anastomoses are examined with a hyperspectral camera and after this the investigators use the Standard Routine ICG-Imaging. At the end, both methods will be compared..

  • 0 views
  • 19 Feb, 2024
Organ Preservation Program Using Short-Course Radiation & FOLFOXIRI in Rectal Cancer

The purpose of the research is to evaluate whether both chemotherapy and radiotherapy can lead to higher rates of clinical complete response leading to organ preservation in human subjects with cancer. The objective is to learn if this treatment approach may safely be used as an alternative to the standard …

serum pregnancy test
cancer
xelox
blood transfusion
mri pelvis
  • 0 views
  • 19 Feb, 2024
Moisturizer Mediated Prevention of Symptoms of Atopic Dermatitis in Early Childhood

In this study, it will be investigated if symptoms of atopic dermatitis of children with high familial risk will be delayed beyond the 6th or even 12th month of life by applying the SanaCutan Basiscreme.

atopy
dermatitis
  • 0 views
  • 19 Feb, 2024
Determination Safety and Tolerability of Epigenetic and Immunomodulating Drugs in Combination With Chemotherapeutics in Patients Suffering From Advanced Pancreatic Cancer.

A multi-center, open-label phase I/II study to to determine the safety and tolerability of Azacitidine and/or Romidepsin in combination with nab-Paclitaxel/Gemcitabine in patients with advanced pancreatic ductal adenocarcinoma (PDAC) (Part 1), followed by sequential immune targeting with programmed death-ligand (PD-L)1 blockade in combination with low-dose Lenalidomide (Part 2) in patients …

cancer
pancreatic cancer
measurable disease
antineoplastic
paclitaxel
  • 0 views
  • 19 Feb, 2024
Nedaplatin Versus Cisplatin in Treatment for Nasopharyngeal Carcinoma

To compare the effectiveness and toxicity of nedaplatin versus cisplatin in induction chemotherapy combined with concurrent chemoradiotherapy for locoregionally advanced nasopharyngeal carcinoma.

nedaplatin
cisplatin
cancer
karnofsky performance status
renal function test
  • 0 views
  • 19 Feb, 2024
A Study to Compare Different Ways of Steroid Administration After Total Knee Implantation

We are going to evaluate the difference between perioperative intravenous steroid supplementation, perioperative periarticular steroid supplementation, and standard anaesthesia protocols. We'll evaluate the outcome of patients with knee osteoarthritis who are undergoing Total Knee Arthroplasty to understand which of the three treatments give more benefits to the patient.

osteoarthritis
anesthesia
total knee replacement
dexamethasone
dexamethasone sodium phosphate
  • 0 views
  • 19 Feb, 2024