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Found 151 clinical trials
Ipatasertib + Atezolizumab to Prevent Recurrence in TNBC

The purpose of this study is to determine if a combination of two drugs ipatasertib and atezolizumab works as a treatment for residual cancer in the breast or lymph nodes and have circulating tumor DNA in the blood. This research study involves the following investigational drugs: Ipatasertib Atezolizumab

g-csf
cfdna
adjuvant therapy
immunohistochemistry
invasive breast cancer
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  • 19 Feb, 2024
Strain vs. Left Ventricular Ejection Fraction-based Cardiotoxicity Prevention in Breast Cancer

Comparing preventive effect of myocardial global longitudinal strain-based cardioprotective stragety (angiotensin receptor blocker prophylaxis) with left ventricular ejection fraction-based strategy in breast cancer patients treated with adjuvant trastuzumab.

immunomodulators
her2+ breast cancer
trastuzumab
angiotensin
anthracyclines
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  • 19 Feb, 2024
The TARGET-EFT Trial

Randomized clinical trial to determine whether a multicomponent intervention will lead to improvements in mobility, self-care, mood, pain, and physical activity among frail and pre-frail older adults (as measured with the Essential Frailty Toolset; EFT) hospitalized for an acute cardiovascular illness.

malnutrition
anemia
  • 0 views
  • 19 Feb, 2024
Comparison Between Two Rates of Activation of Miniscrew-Supported Upper Jaw Expander in Adolescents

The purpose of the clinical trial is to evaluate and compare the effects of slow and rapid activation rates of miniscrew-supported expanders on the skeletal changes, dento-alveolar changes and the pain experience.

maxillary expansion
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  • 19 Feb, 2024
Thoracic Interfascial Plane Block Versus Thoracic Paravertebral Block in Gynecomastia Surgery

The growing increase in the number of gynecomastia surgeries has resulted in an increased need for anesthetic techniques with improved pain reduction, safety, and fewer complications. The aim of this work is to compare the efficacy of ultrasound guided thoracic interfascial plane block and ultrasound guided thoracic paravertebral block for …

local anesthesia
local anesthetics
gynecomastia
anesthesia
  • 0 views
  • 19 Feb, 2024
A Long Term Follow-Up Study of Fabry Disease Subjects Treated With FLT190

Current treatment for Fabry disease is limited to the symptomatic management of pain, conventional management of complications, and methods to increase the availability of functional GLA. This clinical study aims to investigate the long-term safety and durability of GLA in patients who have been dosed with a new gene therapy …

breakdown
fabry's disease
deficiency
gene therapy
glycosphingolipids
  • 0 views
  • 19 Feb, 2024
Effectiveness and Acceptability of MINDFULNESS by Smartphone for Patients With Chronic Migraine and Medication Overuse

This preliminary study will be conducted on 25 patients that have been submitted to a withdrawal according to the standard procedure at our hospital and they will practice mindfulness daily by a standard session of 12 minutes on their smartphone recorded by the expert who generally manage their sessions at …

chronic migraine
therapeutic process
migraine
analgesia
  • 0 views
  • 19 Feb, 2024
Radiotherapy 3 vs 6 Gy in Gonarthrosis and Coxarthrosis

Once the treatment is finished, patients will be assessed at 8 weeks. If pain does not improve, a re-irradiation will be performed. If the patients were treated with 3 Gy a new randomization will be performed (3 vs 6 Gy again).

osteoarthritis
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  • 19 Feb, 2024
Regulated Expiratory Breathing Method During Childbirth

During labor, expiration channeled by a flow regulator device offers support to women enduring the pain of uterine contractions. During the second stage, the expiratory regulated pushing allows a long, efficient and very intuitive push.

cesarean section
vaginal delivery
  • 0 views
  • 19 Feb, 2024