Torento, Canada Clinical Trials

A listing of Torento, Canada clinical trials actively recruiting patients volunteers.

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Found 67 clinical trials
Topotecan Episcleral Plaque for Treatment of Retinoblastoma

This single site, single-arm, non-randomized, dose escalation phase I toxicity clinical trial will assess primarily the safety and secondarily the efficacy of episcleral topotecan in patients with active residual or recurrent intraocular retinoblastoma in at least one eye following completion of first-line therapy.

intraocular retinoblastoma
platelet count
topotecan
brachytherapy
renal function
The Hospital for Sick Children
 (0.4 away) Contact site
  • 0 views
  • 19 Feb, 2024
  • 1 location
Blood-Brain-Barrier Disruption With Cerezyme in Patient's With Parkinson's Disease

This clinical trial focus on the delivery of Cerezyme in Parkinson's Disease (PD) patients using MR-guided focused ultrasound (MRgFUS) induced opening of the blood-brain barrier (BBB).

parkinson's disease
Sunnybrook Health Sciences Centre
 (4.7 away) Contact site
  • 16 views
  • 19 Feb, 2024
  • 1 location
A Study of Tirzepatide (LY3298176) Compared With Dulaglutide on Major Cardiovascular Events in Participants With Type 2 Diabetes

The purpose of the trial is to assess the efficacy and safety of tirzepatide to dulaglutide in participants with type 2 diabetes and increased cardiovascular risk.

cardiovascular disease
body mass index
tirzepatide
dulaglutide
Diabetes Heart Research Center
 (2.1 away) Contact site
  • 0 views
  • 19 Feb, 2024
  • +650 other locations
Durvalumab With or Without Olaparib as Maintenance Therapy After First-Line Treatment of Advanced and Recurrent Endometrial Cancer

A study to assess the efficacy and safety of durvalumab in combination with platinum-based chemotherapy (paclitaxel + carboplatin) followed by maintenance durvalumab with or without olaparib for patients with newly diagnosed advanced or recurrent endometrial cancer.

measurable disease
carcinoma
olaparib
carcinosarcoma
durvalumab
Research Site
 (0.5 away) Contact site
  • 0 views
  • 19 Feb, 2024
  • +94 other locations
Cognitive Outcomes After Dexmedetomidine Sedation in Cardiac Surgery Patients

Anesthesia is a drug induced, reversible, comatose state that facilitates surgery and it is widely assumed that cognition returns to baseline after anesthetics have been eliminated. However, many patients have persistent memory impairment for weeks to months after surgery. Cardiac surgery appears to carry the highest risk of postoperative cognitive …

cardiac surgery
memory impairment
cognitive deficit
coronary artery bypass graft
heart surgery
Sunnybrook Health Sciences Centre
 (4.7 away) Contact site
  • 0 views
  • 19 Feb, 2024
  • 1 location
A Study of Donanemab (LY3002813) in Participants With Early Alzheimer's Disease (TRAILBLAZER-ALZ 2)

The reason for this study is to see how safe and effective the study drug donanemab is in participants with early Alzheimer's disease.

alzheimer's disease
florbetapir
flortaucipir
positron emission tomography
mini-mental state examination
Toronto Memory Program
 (7.4 away) Contact site
  • 0 views
  • 19 Feb, 2024
  • +85 other locations
A Phase 3 Study to Evaluate Efficacy and Safety of AL001 in Frontotemporal Dementia (INFRONT-3)

A phase 3 double blind, placebo controlled study evaluating the efficacy and safety of AL001 in participants at risk for or with frontotemporal dementia due to heterozygous mutations in the progranulin gene.

aphasia
dementia
progranulin
pick's disease
The University of Western Ontario
 (104.0 away) Contact site
  • 0 views
  • 19 Feb, 2024
  • +46 other locations
A Study of Lasmiditan (LY573144) Treatment in Children Aged 6 to 17 With Migraine

The reason for this study is to see if lasmiditan is safe and effective in children aged 6 to 17 with migraine. The study will last up to 20 weeks and may include up to 4 visits.

preventive medication
ly573144
lasmiditan
treatment regimen
headache
Women's College Hospital
 (0.6 away) Contact site
  • 0 views
  • 19 Feb, 2024
  • +162 other locations
ZYNRELEF® for Postoperative Analgesia After Laparoscopic Sleeve Gastrectomy (HeronBariatric) PUBLISHED

Approximately 120 subjects will be randomized into 1 of the following 2 treatment groups in a 1:1 ratio:Group 1: ZYNRELEF® up to 200 mg/ 6mg ( 7ml vial) via instillation at all incision sites in addition to 30 ml of 0.5% Ropivacaine + 10mg dexamethasone. Postoperatively, intermittent IV acetaminophen will …

New Site for Canada
 (7.1 away) Contact site
  • 0 views
  • 09 Jul, 2026
  • +3 other locations
None

Sunnybrook Health Sciences Centre
 (4.7 away) Contact site
  • 0 views
  • 19 May, 2025
  • +19 other locations