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Quantifying Oxygen Utilization of Tumors Using Oxygen-Enhanced Molecular MRI

Quantifying Oxygen Utilization of Tumors Using Oxygen-Enhanced Molecular MRI

Recruiting
100 years and younger
All
Phase N/A
  • Simplified description (AI rewritten)
  • Technical description (Original)

PRIMARY OBJECTIVES:

I. Determine the safety, feasibility, and sensitivity of oxygen-enhanced molecular magnetic resonance imaging (MRI) in healthy volunteers.

II. Measure oxygen-enhanced molecular MRI characteristics in human brain tumors.

OUTLINE

Participants undergo arterial spin labeling (ASL) MRI scan and amine chemical exchange saturation transfer spin-and-gradient echo echo-planar imaging using amine proton CEST echo spin-and-gradient echo (SAGE) EPI (CEST-SAGE-EPI) while breathing normal room air (21% oxygen). Patients then undergo another ASL MRI and CEST-SAGE-EPI while breathing medical grade air (100% oxygen). Total ASL MRI and CEST-SAGE-EPI imaging scan time is 60 minutes.

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Study details
    Malignant neoplasm of brain

NCT04460495

Jonsson Comprehensive Cancer Center

19 February 2024

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