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Assessment of Olfactory Dysfunction in SARS CoV-2 (COVID-19) Infection

Assessment of Olfactory Dysfunction in SARS CoV-2 (COVID-19) Infection

Recruiting
18-85 years
All
Phase N/A

The main objective of this study is to evaluate olfactory acuity by means of a multidimensional assessment protocol to objectively demonstrate the severity of olfactory dysfunction in patients diagnosed with SARS CoV-2. The University of Pennsylvania Smell Identification Test (UPSIT) will be used to assess olfactory function in newly diagnosed patients and also existing patients longitudinally over a 12-month period. This is to document onset (where possible) and rate of progress of olfactory dysfunction.

In relevant cases, the investigators will correlate their findings with severity of the Acute Respiratory Distress Syndrome (ARDS) arising as a result of the infection - characterised as mild, moderate and severe according to the Berlin classification. The investigators will therefore determine if the degree of olfactory dysfunction correlates in any manner to the severity of ARDS developed in a positive SARS CoV-2 patient and if it offers any prognosticative applications.

The investigators will also examine the impact of the symptom of olfactory dysfunction on patient Quality of Life using two validated tools known as the Questionnaire of Olfactory Disorders for English speakers (eQOD) and the SNOT-22 questionnaire.

Furthermore, outcomes will be explored and stratified in terms of age, gender and ethnicity

Study details
    Intrauterine Growth Retardation
    Anosmia
    Quality of life
    COVID19
    Olfactory Disorder
    SARS-CoV-2

NCT04466982

Cambridge University Hospitals NHS Foundation Trust

19 February 2024

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