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Intervening With Opioid-Dependent MothersMothers and Infants

Intervening With Opioid-Dependent MothersMothers and Infants

Recruiting
18-89 years
Female
Phase N/A

Pregnant mothers will be randomly assigned to receive the modified ABC intervention or the control intervention (modified DEF). Hypotheses relate to parent and child outcomes associated with the intervention. Hypothesis 1: Compared to mothers who receive the control intervention, mothers who receive the mABC intervention will show more nurturing and sensitive parenting, enhanced neural activity during parenting-relevant tasks, and more normative patterns of DNA methylation, autonomic nervous system activity, and cortisol production. Hypothesis 2: Compared to infants of mothers who receive the control intervention, infants of mothers who receive the mABC intervention will show more organized and secure attachment patterns, better behavioral regulation during stressors, more advanced social-emotional development, and more normative patterns of DNA methylation, autonomic nervous system activity, and cortisol production. Hypothesis 3: Enhanced maternal sensitivity will mediate effects of the mABC intervention on improved infant outcomes.

Study details
    Parenting
    Drug abuse
    substance abuse
    Child Development
    Opioid Dependence
    Opioid Use Disorder
    Opioid Use Disorder
    substance abuse

NCT04454645

University of Delaware

19 February 2024

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