Multimodal Imaging in the Study of Disorientation in the Hospital

  • STATUS
    Recruiting
  • participants needed
    50
  • sponsor
    University Medical Center Rostock
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Updated on 19 February 2024
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alzheimer's disease
cognitive impairment
mini-mental state examination
dementia
mild cognitive impairment
confusion
mental state examination
mental state exam

Summary

The purpose of this study is to investigate whether markers of brain structure and function from MRI are associated with different levels of spatial orientation and gait parameters in people with mild cognitive impairment or dementia due to Alzheimer's disease when walking through a real world environment.

Description

This is an experimental cross-sectional study which primarily aims at identifying characteristic features of spatial disorientation among people with mild cognitive impairment and dementia. The features of interest are motion and physiological related changes that occur during instances of spatial disorientation, which will be derived from wearable sensors.

Additionally, brain structure and functional connectivity changes associated with different levels of spatial orientation and gait parameters will also be investigated through resting-state functional imaging.

Details
Condition Confusion, Dementia, Dementia, Magnetic Resonance Imaging, Alzheimer's Disease, Alzheimer's Disease, Older Adults, Mild Cognitive Impairment
Age 50years - 100years
Clinical Study IdentifierNCT04387357
SponsorUniversity Medical Center Rostock
Last Modified on19 February 2024

Eligibility

 Yes No Not Sure

Inclusion Criteria

years and above
Mini mental state examination (MMSE) 12 < 28 points for experimental group
Mini mental state examination (MMSE) 28 points for control group
Sufficient knowledge of German to understand participant information, declaration of consent and questionnaires
Dated and signed declaration of consent
Sufficient mobility and motivation to participate in the study

Exclusion Criteria

Less than 50 years
Significantly impaired vision or hearing
Severely reduced mobility: cannot move around independently (even with aids)
Clear my responses
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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