Study on Physiologic Requirement and Dietary Recommended Nutrient Intake (RNI) of Iodine in Children

  • STATUS
    Recruiting
  • participants needed
    600
  • sponsor
    Tianjin Medical University
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Updated on 19 February 2024
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Summary

Iodine is one of essential micronutrient for human, both iodine deficiency and excess will be harmful for human health. Children is the susceptible population to iodine nutrition, and studies show that even mild iodine deficiency would affect the growth and development of children, so it is urgent to identify the dietary recommended nutrient intake (RNI) of iodine for children to guide children scientifically and safely supplement iodine. There are few studies about the dietary recommended nutrient intake (RNI) of iodine in children, and present data are old and outdated.

Description

Based on the investigators'previous study on upper safe level of iodine on children from areas with high iodine in drinking water, this study will conduct an epidemiological study on 600 children living in areas with high water iodine content but the actual iodine content in participants' drinking water is not so high, while no supply of iodized salt.

Meanwhile, in order to get iodine dietary recommended nutrient intake (RNI) values of children. The investigators will conduct a iodine balance experiment on children with sufficient iodine nutrition. We will randomly select thirty healthy students for a three-day iodine balance experiment from the cross-sectional study. The investigators will use the regression model to obtain an iodine intake value when children at"zero iodine"balance. Combine the study at population and individual level, the investigators will obtain data on dietary recommended nutrient intake (RNI) of iodine for Chinese children, to properly guide children iodine supplementation to avoid iodine deficiency, which also will provide data for the update of Chinese dietary reference intakes of iodine.

Details
Condition Nutritional Requirement
Age 7years - 11years
Treatment No intervention
Clinical Study IdentifierNCT04419103
SponsorTianjin Medical University
Last Modified on19 February 2024

Eligibility

 Yes No Not Sure

Inclusion Criteria

Normal body mass index and thyroid function have not been treated for thyroid
disease have not used amiodarone and other drugs (including iodine
supplements) during the investigation have no major diseases and family
history have lived in the local area for more than 5 years

Exclusion Criteria

Long-term low-protein long-term low-heat energy malnutrition
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