Histological Genetic and Epigenetic Analysis of Procedures Related With Dental Implants

  • STATUS
    Recruiting
  • End date
    Dec 20, 2025
  • participants needed
    200
  • sponsor
    Simón Pardiñas López
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Updated on 19 February 2024
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periodontal disease

Summary

In this study genomic, proteomic and histological technologies for the search and characterization of epigenetic modifications and molecular or protein markers, useful in the diagnosis and progression of peri-implant diseases and prevention of implant failure will be used.

Description

Samples stored at the Biomedical Research Institute of A Corua, Xerencia Integrated Management of A Corua (University Hospital Center of A Corua), belonging to the collection of the line of research "Oral Health and Systemic Relationship" with registration n 2017/104 will be used for the realization of the present study.

Nucleic acid extraction and histological analysis of the samples will be performed to evaluate the functional epigenetic modifications associated with peri-implant diseases, in an exploratory manner.

Details
Condition Peri-Implantitis, Peri-implant Mucositis, Implant Complication, Implant Tissue Failure
Age 20years - 90years
Treatment Gingival and bone sample collection, Healthy individuals
Clinical Study IdentifierNCT04421066
SponsorSimón Pardiñas López
Last Modified on19 February 2024

Eligibility

 Yes No Not Sure

Inclusion Criteria

b'The subjects must have read, understood and signed an informed consent regarding the'
b'obtaining of biological samples and participation in the research line of "Oral Health'
b'and Systemic Relationship" existing in the Pardi\\xf1as Dental Medical Clinic and approved'
b'by the ethical committee.'
b'The subjects must be between 20-90 years of age.'
b'Subjects must be non-smokers or former smokers who have quit smoking for at least one'
b'year prior to enrollment in the study.'
b'In addition to the general criteria listed, samples of a healthy periodontal subject must'
b'meet the following criteria when reviewing their medical and dental history :'
b'Subjects do not have or have had a history of periodontal disease, as described in the "'
b'2017 World Workshop on the Classification of Periodontal and Peri- Implant Diseases and'
b'Conditions "'
b'Samples from a subject with peri-implant disease must meet the following criteria:'
b'Samples of subjects who have at least one implant - supported prosthesis for at least 12'
b'months and affected by peri- implant disease according to the " 2017 World Workshop on the'
b'Classification of Periodontal and Peri-Implant Diseases and Conditions "'

Exclusion Criteria

b'Samples of pregnant or lactating women at the time of collection.'
b'Samples of subjects who were taking antibiotics within 1 month before collection of'
b'the sample.'
b'Samples of subjects with chronic use of non-steroidal anti-inflammatory drugs for more'
b'than 3 weeks at the time of sample collection. The use of aspirin in low doses (\\u226481 mg'
b'/ day) will be allowed .'
b'Samples from subjects with disease in the mucosa in the area located around the site'
b'of sample collection.'
b'Samples of subjects with a systemic disease that would exclude the analysis (for'
b'example, severe medical problems, bone metabolism disorders, uncontrolled bleeding'
b'disorders, depressed immune system, diseases that require the periodic use of'
b'teroids, uncontrolled endocrine disorders) .'
b'Samples of subjects with a history of local irradiation therapy in the head / neck'
b'area.'
b'Samples of subjects with a history of having received treatment with intravenous or'
b'ubcutaneous antiresorptive agents associated with osteonecrosis of the jaw, such as'
b'bisphosphonates.'
b'Samples of subjects assigned to the healthy group that meet any of the following criteria'
b'will be excluded from participation in this study:'
b'Root fragments, pericoronaritis, endo-perio lesions, dental abscesses at the site of'
b'the biopsy.'
b'Presence of BOP in the sample collection site.'
b'Peri- implant disease samples / Exclusion of Subjects'
b'The samples of the subjects assigned to the peri- implant diseases group that meet any of'
b'the following criteria will be excluded from participation in this study if the implants'
b'were removed due to:'
b'Inadequate position of the implant.'
b'Subjects with implants previously treated surgically for peri- implant disease with'
b'antibiotics.'
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