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Decitabine With Ruxolitinib or Fedratinib for the Treatment of Accelerated/Blast Phase Myeloproliferative Neoplasms

Decitabine With Ruxolitinib or Fedratinib for the Treatment of Accelerated/Blast Phase Myeloproliferative Neoplasms

Recruiting
18 years and older
All
Phase 2
  • Simplified description (AI rewritten)
  • Technical description (Original)
OUTLINE

Patients receive decitabine intravenously (IV) once daily (QD) over 1 hour on days 1-10, and either ruxolitinib orally (PO) twice daily (BID) or fedratinib daily on days 1-28. Treatment repeats every 28 days for up to 6 cycles in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up for up to 5 years.

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Study details
    Preleukemia
    Acute myeloid leukemia
    Acute myeloid leukemia
    Myelodysplastic-Myeloproliferative Diseases
    Myelosclerosis with myeloid metaplasia
    MYELOPROLIFERATIVE DISORDER
    MYELODYSPLASTIC SYNDROME
    ESSENTIAL THROMBOCYTHEMIA
    Polycythemia Vera
    Myeloproliferative Neoplasm
    Unclassifiable
    Secondary Myelofibrosis

NCT04282187

University of Washington

19 February 2024

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