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Change of NLRP3 Inflammasome Expression Level Symptoms and Functional Status in HFpEF Patients Treated With ARNI

Change of NLRP3 Inflammasome Expression Level Symptoms and Functional Status in HFpEF Patients Treated With ARNI

Recruiting
100 years and younger
All
Phase N/A
  • Simplified description (AI rewritten)
  • Technical description (Original)

The study will integrate data from two trials involving a total of 90 participants with heart failure. Depending on the using of ARNI, participants in HFpEF group will be divided into two groups. The diagnostic criteria for HFpEF is: (1) left ventricular ejection fraction 50% (2with the symptoms and/or signs of heart failure; (3) BNP35 pg/mL and/or NTproBNP125 pg/mL; (4) at least one additional criterion: a.relevant structural heart disease(LVH and/or LAE); b.diastolic dysfunction. The primary outcome are the change from baseline in TNF, IL-1, NLRP3 inflammasome, and so on assessed at 12 weeks. The key secondary outcomes include changes in echocardiographic measures, quality of life, etc. And then compare the rate of above indicators of two trials.

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Study details
    Heart failure
    Heart failure
    Heart disease
    Heart disease

NCT04269057

Chongqing Medical University

19 February 2024

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