This is a phase I/Ib, open-label, global, multi-center study of subcutaneously administered NIZ985 alone and in combination with Spartalizumab in subjects with advanced solid tumors and lymphoma who have progressed after obtaining a previous response to anti-PD-1/ Check Point Inhibitor (CPI) therapy.
The study consists of two parts, dose escalation and dose expansion. Two separate arms will be examined during the escalation portion: 1) evaluation of NIZ985 as a single agent. Spartalizumab may be added at the time of the first disease re-evaluation and 2) administration of NIZ985 and Spartalizumab as a combination starting from Cycle 1Day 1.
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