Primary Objectives: A pilot Study to evaluate the feasibility, safety and tolerability of a two day course per cycle of Bendamustine plus CPI-613 in patients with relapsed and refractory T cell non-hodgkin lymphoma.
Exploratory Objectives
To evaluate:
- Overall response rate (ORR) and disease control rate (DCR) derived from the Lugano classification.
- Duration of response (DOR) derived from the Lugano classification.
- Progression-Free-Survival (PFS) derived from Lugano classification.
- Overall Survival (OS).
- Single cell transcriptomics from PMBCs pre- and post-treatment; for correlative analyses of blood PBMC (and possibly excess pre-treatment tumor biopsy) cell population diversity and functional states to reveal potential mechanisms of drug treatment with regard to patient response status.
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