Overview
It is not previously investigated whether, there is a correlation between potassium channels
and migraine, so it is unclear whether, this signaling pathway through potassium channels has
an impact on migraine pathophysiology.
Maxipost (BMS 204352) is a vasoactive molecule that causes vasodilation via the big calcium
dependent potassium (BKCa) channel signaling pathway. Maxipost decreases the blood pressure
and maxipost infusion causes headache in healthy volunteers. A possible coherence between
maxipost and headache/migraine in healthy volunteers and migraine patients is yet to be
investigated.
The present study aims to clarify a possible coherence between maxipost and headache/migraine
and it will help to shed light on the importance of potassium channels in migraine. In
general, the study will contribute to a greater understanding of migraine pathogenesis and
possibly lead to development of specific migraine treatment.
Description
Eligibility
Inclusion Criteria:
- Migraine patients without aura who fulfill criteria in the international classification of headaches. This does not apply to healthy volunteers.
- 18-60 years.
- 50-90 kg.
- Women of childbearing potential must use adequate contraception.
Exclusion Criteria:
- Headache less than 48 hours before the tests start
- All primary headaches, except migraine without aura for migraine patients, according to international classification of headache
- Daily consumption of drugs of any kind other than oral contraceptives
- Pregnant or nursing women.
- Cardiovascular disease of any kind, including cerebrovascular diseases.
