Meal Response, Protein, and PCOS

  • STATUS
    Recruiting
  • End date
    Jun 30, 2027
  • participants needed
    30
  • sponsor
    University of Arkansas, Fayetteville
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Updated on 28 August 2025
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Summary

Polycystic ovary syndrome (PCOS) is a common endocrine disorder characterized by insulin resistance, hyperandrogenism, and reproductive dysfunction. Dietary strategies that improve postprandial insulin and glucose responses are central to managing metabolic symptoms in PCOS. Protein-rich meals can attenuate postprandial glycemia and enhance satiety, but the effects may vary by protein source. Animal proteins typically have higher leucine content and insulinogenic potential, whereas plant proteins offer fiber and phytochemicals that may influence glycemic dynamics differently. Few studies have directly compared the acute metabolic effects of plant versus animal protein in women with PCOS. Given the distinct pathophysiology of PCOS, extrapolating findings from healthy populations may be misleading. Understanding protein-specific effects on postprandial insulin, glucose, and appetite-regulating hormones in this group is essential for targeted nutrition guidance. Additionally, plant-based diets are increasingly promoted for cardiometabolic health, but their acute effects in insulin-resistant women remain underexplored. This study will assess whether plant and animal protein meals elicit differential postprandial responses in women with PCOS. Findings may inform dietary recommendations aimed at improving metabolic outcomes in this high-risk population.

Details
Condition Polycystic Ovary Syndrome (PCOS)
Age 18years - 50years
Clinical Study IdentifierNCT07142603
SponsorUniversity of Arkansas, Fayetteville
Last Modified on28 August 2025

Eligibility

 Yes No Not Sure

Inclusion Criteria

Females ages 18-50 years
Confirmed diagnosis of PCOS
Body mass index (BMI) between 18.5 and 35 kg/m2
Stable body weight for at least 3 months (+ 5 pounds)
Willingness to consume both plant- and animal-based protein meals

Exclusion Criteria

Smoking or use of nicotine products
Smoking or use of marijuana products
Food allergies or dietary restrictions incompatible with test meals
Diagnosed diabetes (type 1 or 2)
Use of medications that interfere with study outcomes (e.g., metformin, GLP-1 agonists, etc.)
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