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Lymph Node Aspiration to Decipher the Immune Response of Beta-variant Recombinant Protein Booster Vaccine (VidPrevtyn Beta, Sanofi) Compared to a Bivalent mRNA Vaccine (Comirnaty Original/Omicron BA.4-5, BioNTech-Pfizer) in Adults Previously Vaccinated With at Least 3 Doses of COVID-19 mRNA Vaccine.

Investigation of Lymph Node Response in Areas Where B Cells Mature Post-Vaccine Boost

Recruiting
18 years and older
All
Phase 0
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study investigates the response of germinal centers in lymph nodes after receiving a booster vaccine.

Participants will undergo a procedure called fine needle aspiration to collect samples from their lymph nodes.

  • Who can participate: Adults aged 18 years and older who are part of the COVIBOOST 2 study can participate.
  • Study details: Participants will undergo a procedure to collect samples from lymph nodes and provide blood samples.
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Study details
    COVID-19

NCT05951920

Assistance Publique - Hôpitaux de Paris

22 May 2025

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