Comparative Efficacy of Pregabalin and Lacosamide in Patients With Herpes Zoster and Post Herpetic Neuralgia

  • STATUS
    Recruiting
  • End date
    Sep 30, 2025
  • participants needed
    50
  • sponsor
    CMH Kharian Medical College
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Updated on 14 May 2025
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Summary

Post-herpetic neuralgia (PHN) is the most significant complication of herpes zoster caused by reactivation of latent Varicella-Zoster virus (VZV). PHN is characterized by neuropathic pain lasting beyond the resolution of the rashes. Post herpetic neuralgia (PHN) represents a potentially debilitating and often undertreated form of neuropathic pain that disproportionately affects vulnerable populations, including the elderly and the immunocompromised. PHN pain is typically localized, unilateral and chronic, but may be constant, intermittent, spontaneous and/or evoked. PHN is likely to interfere with sleep and daily activities.

Pregabalin is a gabapentinoid licenced for treatment of neurological disorders. It is one of the earlier drugs approved by the US Food and Drug Administration (2004) for the treatment of painful diabetic neuropathy and postherpetic neuralgia (PHN). Lacosamide (LCM) was approved in 2008 in the European Union and in the United States as adjunctive therapy for the treatment of focal-onset seizures with or without secondary generalization in adults and adolescents with epilepsy. Its efficacy has also been proven in neuropathic pain.

Although Pregabalin and Lacosamide have proven effective in various neuropathic pain disorder, comparative studies specifically for PHN remain scarce. This study aims to compare the efficacy of Pregabalin and Lacosamide in PHN patients, addressing the current gap in literature and providing clinically relevant insights to optimize treatment selection.

Details
Condition Herpes Zoster (HZ), Post Herpetic Neuralgia (PHN)
Age 18years - 50years
Clinical Study IdentifierNCT06969417
SponsorCMH Kharian Medical College
Last Modified on14 May 2025

Eligibility

 Yes No Not Sure

Inclusion Criteria

Diagnosed cases of herpes zoster suffering from postherpetic neuralgia
Ages: 18 to 50
Both male and female

Exclusion Criteria

Lack of consent
Patient already taking pain killers for post herpetic neuralgia
Patients suffering from other systemic illness
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