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Modulation of GABA-A Receptors in Parkinson Disease-Transdermal Flumazenil Arm

Modulation of GABA-A Receptors in Parkinson Disease-Transdermal Flumazenil Arm

Recruiting
50 years and older
All
Phase 1/2
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  • Technical description (Original)

This study focuses on neurochemical changes in the brain that occur in Parkinson's disease. In particular we will be looking a neurotransmitter called GABA. In some Parkinson's disease patients we see too much GABA activity in the brain. This target engagement study examines the target engagement effect of GABA-A receptor modulation by transdermal flumazenil (previously clarithromycin). [11C]-flumazenil Positron Emission Tomography (PET) imaging results will be used to assess for possible GABA-A receptor target engagement effects of transdermal flumazenil (previously clarithromycin).

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Study details
    Parkinson's Disease
    Parkinson's Disease

NCT03440112

Nicolaas Bohnen, MD, PhD

19 February 2024

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