Overview
The purpose of this study is to assess the safety and tolerability of a 6-week Inspiratory
Muscle Training and cardiovascular exercise training program in children and adolescents with
asthma.
To also determine the efficacy of inspiratory muscle training and exercise in increasing
respiratory muscle strength and endurance, and to explore relationships between fitness
interventions (inspiratory muscle training and exercise), exercise tolerance, airway closure
and dyspnea scores.
Description
Eligibility
Inclusion Criteria:
- 10-17 years of age
- Clinician-diagnosed asthma
- Sedentary activity defined as having not participated in a sports team or formal activity (dance classes, gym membership, active hobby requiring physical activity) in the past 12 months or have a
- Body mass index (BMI) 85th percentile (adjusted for sex and age)
- Child must have a designated caregiver who expresses a commitment to encourage the participant to attend weekly clinic-based exercise and also complete additional home exercise.
Exclusion Criteria:
- Previous intubation for asthma,
- Forced expiratory volume in 1 second (FEV1) < 50% of predicted at enrollment;
- Any major chronic illness that in the opinion of the PI would interfere with participation in the intervention or completion of the study procedures;
- Inability to complete baseline measurements in a satisfactory manner according to the judgment of the research coordinator or PI
- Currently active in sports, vigorous play or planned exercise more than 1 time per week on average over the past month
- Current Pregnancy as determined by urine pregnancy test.
- Parent/Caregiver unable to consent in English
