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Camrelizumab in Combination With Apatinib in Refractory and Relapsed DLBCL

Camrelizumab in Combination With Apatinib in Refractory and Relapsed DLBCL

Recruiting
18-80 years
All
Phase 1/2

Patients with relapsed /refractory diffuse large B cell lymphoma usually have a bad prognosis. These patients cannot be treated successfully with the conventional chemotherapy of CHOP. Apatinib is a new type of oral tyrosine kinase inhibitor targeting VEGFR-2. Some studies have shown that the combination of low-dose apatinib and camrelizumab shows a synergistic effect in the exploration of multiple solid tumors, and the adverse reactions of low-dose apatinib are significantly reduced, and the patients are well tolerated.The investigators will evaluate the efficacy and safety of camrelizumab in combination with apatinib in the patients with relapsed refractory diffuse large B cell lymphomafailed from second line chemotherapy.

Study details
    Diffuse Large B-Cell Lymphoma
    Transformed Lymphoma
    High-grade B-cell Lymphoma
    Follicular Lymphoma Grade IIIb
    EBV-Positive DLBCL
    Nos
    ALK-Positive Anaplastic Large Cell Lymphoma

NCT04476459

Huiqiang Huang

19 February 2024

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