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FOLFIRINOX vs FLOT Chemotherapy for Resectable Gastric or Esophagogastric Junction Adenocarcinoma

FOLFIRINOX vs FLOT Chemotherapy for Resectable Gastric or Esophagogastric Junction Adenocarcinoma

Recruiting
18-70 years
All
Phase 2/3

538 Patients with resectable (cT4cN0 or cT1-4 and cN+, cM0) adenocarcinoma of the stomach or the esophagogastric junction without previous therapy will be included in this study. After randomization patients receive perioperatively 4 cycles FLOT or FOLFIRINOX, followed by a restaging of the tumour status and surgery. Subsequently another 4 cycles of FLOT or FOLFIRNOX are applicated.

Study details
    Fluorouracil
    Gastrointestinal Neoplasm
    GASTROINTESTINAL DISORDER
    Neoplasm of unspecified nature of digestive system
    Gastropathy
    stomach discomfort
    Gastric Cancer
    Gastric Cancer
    stomach cancer
    stomach cancer
    stomach discomfort
    Docetaxel
    Oxaliplatin
    Irinotecan Hydrochloride

NCT04393584

Blokhin's Russian Cancer Research Center

19 February 2024

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