The Specific Aims of This Study Are As Follows:
- Identify whether sputum anti-CCP predicts incident RA
- Determine the effect of inflammatory cytokines on the induction of NETosis in sputum neutrophils
- Determine the role of sputum macrophage phagocytosis in NET clearance <br> The knowledge gained from this study will improve the overall understanding of the development of RA. It is anticipated that these findings will improve the field's understanding of how best to screen for RA risk and target RA prevention. This study could support future lung-targeted prevention strategies for RA that could avoid the administration of systemic toxic therapies. Such potential prevention interventions could be implemented in subjects at risk for RA in order to prevent the irreversible joint damage that can occur in the later stages of clinically-apparent RA.
How understandable was the trial content above?
Hard to understand
Easy to understand
