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The Efficacy of Adjuvant Chemotherapy in Locally Advanced Cervical Cancer

The Efficacy of Adjuvant Chemotherapy in Locally Advanced Cervical Cancer

Recruiting
18-75 years
Female
Phase N/A
  1. Objective:

To compare response rate and survivals of locally advanced stage cervical cancer patients with residual lesions who had CCRT alone to those who had adjuvant chemotherapy after CCRT.

2. Patients:

  1. Cervical cancer stage IIb to IVa with a histopathology of squamous cell carcinoma, adenosquamous cell carcinoma, adenocarcinoma
  2. Complete CCRT(Radiation Does: A point 85Gy(+/-10%)B50Gy(+/-10%)concurrent paclitaxel and cisplatin once a week for six cycles)
  3. MRI is performed within 4 weeks after CCRT and shows residual lesions (non-lymph node10mmlymph node shortest diameter15mm).
  4. Methods:

The patients who have residual lesions after CCRT are randomized to arm A by observation or arm B by adjuvant chemotherapy with paclitaxel plus cisplatin every 3 weeks for 3 cycles.

Study details
    Cervical Cancer
    Cervical Cancer
    Uterine Cancer
    Uterine Cancer

NCT04409860

Chongqing University Cancer Hospital

19 February 2024

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